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What is a subclass immune deficiency?

What is a subclass immune deficiency?

IgG subclass deficiencies affect only IgG subclasses (usually IgG2 or IgG3), with normal total IgG and IgM immunoglobulins and other components of the immune system being at normal levels. These deficiencies can affect only one subclass or involve an association of two subclasses, such as IgG2 and IgG4.

What does IgG subclass 4 mean?

Introduction. Immunoglobulin subclass 4 (IgG4)-associated diseases are an increasingly recognized group of autoimmune diseases,1,2 which are characterized by sclerosis and lymphoplasmocytic infiltration of affected organs with IgG4-positive cells.

What does normal mean for IgG, subclass 3?

IgG, Subclass 3. Normal values usually represent a small range below and above the average for a person’s age. An additional subset of patients have normal levels of immunoglobulin and normal IgG subclasses, yet fail to develop protective antibody levels in response to infections with Streptococcus pneumoniae or vaccines against the bacteria.

What happens when your IgG level is low?

When IgG levels are low, a person’s exposure to infection development is higher. In newborns, it may just be an indication that the child’s immune system has yet to kick in and begin working. For adults, then the deficiency must have a specific cause and specific testing to determine those causes will be ordered as a follow-up.

How are immunoglobulin levels measured for IgG deficiency?

A blood test that measures immunoglobulin levels is the initial step in diagnosing IgG deficiency. More complicated but very important tests involve the measurement of antibody levels in response to certain vaccinations. How is an IgG deficiency treated?

What is the normal range for IgG4 deficiency?

IgG4 deficiency often occurs in combination with IgG2 deficiency. It’s important to remember that the definition of “normal” IgG subclass concentrations varies over time, and from lab to lab. Normal values usually represent a small range below and above the average for a person’s age.

What does it mean if your IgG, subclass 2 result is too low?

What does it mean if your IgG, Subclass 2 result is too low? – People with persistently low levels of one or two IgG subclasses and a normal total IgG level have a selective IgG subclass deficiency.

A blood test that measures immunoglobulin levels is the initial step in diagnosing IgG deficiency. More complicated but very important tests involve the measurement of antibody levels in response to certain vaccinations. How is an IgG deficiency treated?

IgG4 deficiency often occurs in combination with IgG2 deficiency. It’s important to remember that the definition of “normal” IgG subclass concentrations varies over time, and from lab to lab. Normal values usually represent a small range below and above the average for a person’s age.

Which is the best range for IgG lab results?

A healthy result should fall into the range 41 – 129 mg/dL. There are five classes of antibodies (immunoglobulins) that help the body fight infection: IgG, IgA, IgM, IgD, and IgE. Immunoglobulins make up the antibodies that fight infection.