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What is the drug of choice for myocardial infarction?

What is the drug of choice for myocardial infarction?

The pain of myocardial infarction is usually severe and requires potent opiate analgesia. Intravenous diamorphine 2.55 mg (repeated as necessary) is the drug of choice and is not only a powerful analgesic but also has a useful anxiolytic effect.

What medication is used for myocardial infarction that reduces reinfarction and mortality?

Aspirin. The benefit of aspirin in the secondary prevention of MI is well established. In 791 patients who had MI reviewed by the Antiplatelet Trialists, low to medium doses of aspirin (75-325 mg/day) led to a 12 % reduction in deaths, a 31% reduction in reinfarction and a 42% reduction in non-fatal stroke.

Which drug can be used to prevent secondary heart attack?

The good news, as authors explain, is that adding ticagrelor to low-dose aspirin may significantly reduce risk of a second heart event. It’s estimated that 735,000 Americans suffer a heart attack each year and helping heart attack survivors prevent a second event has the potential to save millions of lives.

Which medication has evidence of mortality benefit in the setting of heart failure following recent MI?

No clinical differences have been demonstrated among beta blockers that have a proven mortality benefit in the treatment of heart failure. Diuretics are included as background therapy.

Why are beta blockers used for MI?

For patients with acute myocardial infarction (MI), beta blocker therapy reduces infarct size and early mortality when started early and lowers the risk of death when continued long term.

Which ARB is best for heart failure?

Drugs called angiotensin receptor blockers (ARBs), such as losartan (brand name: Cozaar), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), telmisartan (Micardis) and valsartan (Diovan) are commonly used to treat heart failure.

Which is better ACE or ARB?

ARBs are preferred for patients who have adverse reactions to ACE inhibitors. (SOR: A, based on a meta-analysis.) ARBs cause less cough than ACE inhibitors, and patients are less likely to discontinue ARBs because of adverse effects.

What is the difference between ACE and ARB?

Stopping the conversion of angiotensin I to angiotensin II results in blood vessel relaxation and a decrease in blood pressure. ARBs also target the angiotensin pathway, but they work by blocking angiotensin II from binding to receptors on the blood vessels that affect blood vessel constriction.

Are ARBs safe for kidneys?

Now results from three landmark studies of almost 4,000 diabetic patients suggest that a specific class of blood pressure drugs called angiotensin receptor blockers, or ARBs, can protect kidneys and reduce the need for kidney dialysis or transplant.

How fast do ARBs work?

It may take many weeks for you to feel the full effects of the drug. While you’re taking an ARB, your doctor will check your blood pressure and test how well your kidneys are working.

Can ARBs increase blood pressure?

This narrowing increases the pressure within the vessels and can cause high blood pressure (hypertension). Angiotensin II receptor blockers (ARBs) are medications that block the action of angiotensin II by preventing angiotensin II from binding to angiotensin II receptors on the muscles surrounding blood vessels.

How much do ARBs lower BP?

The BP lowering effect of ARBs is modest and similar to ACE inhibitors as a class; the magnitude of average trough BP lowering for ARBs at maximum recommended doses and above is ‐8/‐5 mmHg. Furthermore, 60 to 70% of this trough BP lowering effect occurs with recommended starting doses.

How long does it take for ARB to lower blood pressure?

ARBs reduced BP measured 1 to 12 hours after the dose by about 12/7 mm Hg. Authors’ conclusions: The evidence from this review suggests that there are no clinically meaningful BP lowering differences between available ARBs.

What is the safest drug to treat high blood pressure?

Methyldopa, which works to lower blood pressure through the central nervous system, has the lowest risk of harming the mother and developing fetus. Other possible safe options include labetalol, beta blockers, and diuretics.